Normal and abnormal oscillations in the cortico-basal ganglia network revealed by deep brain stimulation recordings
Deep brain stimulation is an effective treatment for patients with advanced movement disorders. It also offers a unique opportunity to record local field potentials from basal ganglia structures in humans. I will give a brief overview of physiological and pathological neural oscillations that have been found and argue that cross-frequency coupling could play an important role in understanding how symptoms of movement impairment in Parkinson’s disease emerge. I will then present our efforts to unravel the origins of abnormal oscillations, both in terms of anatomy and function. This includes a spatial localization study with intra-operative recordings around the subthalamic nucleus, and a dynamic causal modelling study of simultaneous LFP and MEG recordings to infer how beta oscillations arise within the cortico-basal ganglia circuit. These studies give insight into the role of the basal ganglia in movement and movement disorders, and contribute towards optimization of deep brain stimulation treatment.
Dr. Bernadette van Wijk pursued her undergraduate and postgraduate studies in Human Movement Sciences at VU University Amsterdam. During her PhD she focused on the role of beta oscillations in the motor system of healthy individuals using techniques such as EEG, MEG and EMG. Since then she held postdoctoral positions at University College London and the Charité – University Medicine Berlin, where she started to work with LFP recordings from deep brain stimulation electrodes in patients with movement disorders. Using advanced signal processing techniques such as cross-frequency coupling and dynamic causal modelling, she investigates physiological and pathological oscillations within the cortico-basal ganglia network. Bernadette has recently been awarded a Marie Curie Fellowship to relocate to the University of Amsterdam, where she will extend her work into the field of cognitive neuroscience including movement inhibition and decision making.
Date: 12 April 2018
Time: 16.00 – 17.00
Drinks: 17.00 – 18.00
Location: Science Building (W&N-gebouw) – C 623